Abstract
Cerebrospinal fluid GABA was measured in 41 normal volunteers, 16 depressed and eight manic patients during a medication-free evaluation. CSF GABA was measured by modified cation-exchange chromatography. Mean CSF GABA in the normal volunteers was 231.8 ± 12.5 pmole/ ml, nonsignificantly different from that in the depressed patients (209.1 ± 13.8) or manics (211.4 ± 21.7). In one rapidly cylcing patient values during his manic episodes were significantly higher than those during depressed periods ( p<0.05). In the normals CSF GABA was positively correlated ( p<0.05) with CSF norepinephrine and MHPG and negatively correlated with CSF calcium and magnesium. In the depressed patients and in normal females, but not males, GABA was negatively correlated with age. There was no significant correlation between CSF GABA and degree or severity of rated depression, anxiety, or psychosis. Affectively ill patients treated with the anticonvulsant carbamazepine did not demonstrate significant alterations in CSF GABA concentrations.
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