Abstract
IntroductionTubuloreticular inclusions (TRI) were first reported in patients with herpesvirus encephalitis or systemic lupus erythematosus (SLE). TRI are abnormal subcellular structures which consist of fine irregularly branched, anastomosing tubules within cisternae of endoplasmic reticulum. TRI have also been reported in blood lymphoreticular cells, vascular endothelial cells, mesenchymal cells, and epithelial cells in a variety of clinical conditions which include SLE and other autoimmune diseases, congenital immunodeficiency, lymphoproliferative disorders, neoplasms, neurodegenerative disorders, T-cell leukemia, and acquired immune deficiency syndrome (AIDS). We have recently reported an association of TRI with Reye's syndrome (RS). The inclusions were found in peripheral leukocytes of two unrelated patients with RS following a prodromal influenza respiratory infection. Subsequent to those studies we have retrospectively examined biopsy material from earlier cases of RS, and have identified TRI in the capillary endothelial cells from brain biopsies of three RS patients. The purpose of this report is to present these observations and to discuss the association of TRI with RS.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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