Abstract
Pathogenetic role of atrial fibrillation (AF) and nonbacterial thromobotic endocarditis (NBTE) on cerebral embolism was studied in 2340 consecutive autopsies of the aged. Large brain infarcts in patients with AF were more often (21.9%) compared to infarcts in non-AF patients (7.3%). Intracranial cerebral artery athersclerosis was less severe in AF patients with large brain infarcts compared to non-AF patients with large infarcts. NBTE was found in 9.3% of consecutive autopsies and was associated with a high prevalence of large or medium sized brain infarct (49.7%) irrespective of co-existent disseminated intravascular coagulation, implicating embolism as the probable stroke mechanism.KeywordsAtrial FibrillationCerebral InfarctionDisseminate Intravascular CoagulationDisseminate Intravascular CoagulationAtrial Fibrillation PatientThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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