Abstract
Multidetector row CTA has become the primary imaging technique for detecting intracranial aneurysms. Technical progress enables the use of cerebral CTA with lower radiation doses and contrast media. We evaluated the diagnostic accuracy of 80-kV(peak) cerebral CTA with 30 mL of contrast agent for detecting intracranial aneurysms. Two hundred four patients were randomly divided into 2 groups. Patients in group A (n = 102) underwent 80-kVp CTA with 30 mL of contrast agent, while patients in group B (n = 102) underwent conventional CTA (120 kVp, 60 mL of contrast agent). All patients underwent DSA. Image quality, diagnostic accuracy, and radiation dose between the 2 groups were compared. Diagnostic image quality was obtained in 100 and 99 patients in groups A and B, respectively (P = .65). With DSA as reference standard, diagnostic accuracy on a per-aneurysm basis was 89.9% for group A and 93.9% for group B. For evaluating smaller aneurysms (<3 mm), the diagnostic accuracy of groups A and B was 86.3% and 90.8%, respectively. There was no difference in diagnostic accuracy between each CTA group and DSA (all, P > .05) or between the 2 CTA groups (all, P > .05). The effective dose in group A was reduced by 72.7% compared with group B. In detecting intracranial aneurysms with substantial radiation dose and contrast agent reduction, 80-kVp/30-mL contrast CTA provides the same diagnostic accuracy as conventional CTA.
Highlights
BACKGROUND AND PURPOSEMultidetector row CTA has become the primary imaging technique for detecting intracranial aneurysms
For evaluating smaller aneurysms (Ͻ3 mm), the diagnostic accuracy of groups A and B was 86.3% and 90.8%, respectively
85% of all subarachnoid hemorrhages result from ruptured intracranial aneurysms.[1]
Summary
Two hundred four patients were randomly divided into 2 groups. Diagnostic accuracy, and radiation dose between the 2 groups were compared. Patients This prospective study was approved by the Jinling Hospital institutional review board. Inclusion criteria for this study were the following: 1) clinically suspected intracranial aneurysm, that is, patient presentation with subarachnoid hemorrhage or a suspicion of an intracranial aneurysm after medical examinations; 2) clinical referral for both cerebral CTA and DSA when patients were able to undergo the 2 examinations; and 3) cerebral CTA performed before DSA with no more than 3 days between procedures. Included patients who underwent CTA with different tube voltages and different volumes of iodinated contrast agent were randomly divided into 2 groups based on a computer-generated allocation sequence. The baseline characteristics of all patients are presented in On-line Table 1
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
