Abstract
Background The pathogenesis of psoriasis vulgaris is attributed to an immune dysregulation of T lymphocytes, and psoriatic plaques result from interactions between keratinocytes and T lymphocytes. Objective To decipher the impact of keratinocyte-T lymphocyte interactions on cell survival during active cutaneous psoriasis by using a new in vitro model of psoriasis. Methods Cocultures of psoriatic or healthy keratinocytes were performed with normal human blood T lymphocytes. Apoptosis was detected by flow cytometry after labeling cells with annexin V and propidium iodide. Results Psoriatic keratinocytes were significantly more efficient than healthy keratinocytes in enhancing T lymphocyte survival. Conclusion Our in vitro model is pertinent to understanding the immunopathogenesis of psoriasis and to discovering new pharmacological targets.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
