Abstract
Cellular Aging promotes CEMP1 Expression in STRO-1 positive PDL cells
Highlights
The periodontium supports the tooth and consists of the periodontal ligament (PDL), tooth cementum, alveolar bone, and gingiva [1]
Since CEMP-1 is a presumptive marker of mineralization and cementogenesis [17], its expression was examined in these cells
Western blot analyses confirmed that parental PDL cells, STRO-1 positive PDL cells, and control cementoblastoma cells all expressed cementum protein 1 (CEMP1) (Figure 1C)
Summary
The periodontium supports the tooth and consists of the periodontal ligament (PDL), tooth cementum, alveolar bone, and gingiva [1]. The PDL is comprised of a collagenous extracellular matrix and cells, including the cementum- producing cementoblasts [2]. Periodontal regeneration is difficult and requires reconstitution of several tissues, including root cementum, which is not predictable. Steps in this process include attachment of new connective tissue fibers to root surfaces and cementogenesis. Cementogenesis is a critical process for homeostasis and regeneration of the periodontium [4, 5]. Cementum was first described in 1835 and its recognition probably dates back to 1667 [6], it remains poorly understood at the cellular and molecular level
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