Abstract
Migration-inhibition factor (MIF) and delayed skin tests with axenic antigen obtained from Entamoeba histolytica were performed in 13 cases of amebic liver abscess and in 16 control individuals with no clinical or laboratory evidence of amebiasis. All subjects were of low socioeconomic condition, drawn from a community in Mexico City where amebiasis is highly endemic. Patients with amebic liver abscess revealed diminished cell-mediated immunity to E. histolytica antigen when tested by skin tests and for MIF production. Skin reactions to streptokinase-streptodornase were normal. When the same patients were tested 10 days after discharge from hospital, they all had normal delayed-type skin reactions and MIF production to E. histolytica antigen. During liver abscess as well as 10 days after successful treatment, sera from patients disclosed antibodies by counterelectrophoresis and passive hemagglutination tests. The importance of the relationship between performance of the tests and the clinical evolution of the disease is discussed.
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