Abstract
Surface enhanced Raman scattering (SERS) Au nanoparticles have been used as novel cell surface receptor labels for the identification of markers of interest in chronic lymphocytic leukemia (CLL) and lung cancer. Biocompatibility of the particles was improved using multiple coating and particle protection strategies. Each of these strategies facilitated different methods for the inclusion of Raman active reporter molecules, as well as for different types of targeting moieties. Characterization of the SERS nanoparticles was undertaken including quantification of the number of antibodies bound to the surface.
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