Abstract
Firmly established tumors in syngeneic mice will regress if the host is challenged with living tumor cells which have been exposed to Vibrio cholerae neuraminidase (VCN) or Concanavalin A (ConA) in vitro. The effect is totally immunospecific and can be induced only with VCN- or ConA-treated tumor cells identical in type with the growing tumor. The degree of immunoregression is similar when using optimal concentrations of ConA and VCN. The fact that two such different substances can alter the cell surface to increase the immunogenicity of tumor antigens may shed some light on the mechanisms involved.
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