Abstract
The supraneural body was identified in the adult lamprey, and its secretions induced the death of a variety of tumor cells but had no effect on normal cells. The cell secretions from different lamprey tissues were separated, and these secretions killed human tumor cells to varying degrees. The cell secretions induced remarkable cell morphological alterations such as cell blebbing, and the plasma membrane was destroyed by the secretions. In addition, the secretions induced morphological alterations of the mitochondria, cytoskeletal structure, and endoplasmic reticulum, eventually leading to cell death. These observations suggest the presence of a novel protein in the lamprey and the possibility of new applications for the protein in the medical field.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-015-1270-6) contains supplementary material, which is available to authorized users.
Highlights
Bajoghli et al (2011) identified thymus-like lymphoepithelial structures, termed thymoids, in the tips of gill filaments and neighboring secondary lamellae in lamprey larvae, implicating the thymoid as the development site of T-like cells in lampreys
Piavis and Hiatt (1971) confirmed that the fatty tissue rod embedded in the fibro cartilaginous sheath dorsal to the nerve cord is the principal hematopoietic organ
Scientists found that the SB is relative to the hematopoietic organ and comprises immune tissues in the lamprey because numerous immune molecules were identified in the SB of adult lamprey (Amemiya et al 2007)
Summary
Bajoghli et al (2011) identified thymus-like lymphoepithelial structures, termed thymoids, in the tips of gill filaments and neighboring secondary lamellae (both within the gill basket) in lamprey larvae, implicating the thymoid as the development site of T-like cells in lampreys. Hematopoietic activity is located in the typhlosole of the intestine in both larval and adult stages. The kidney and gill regions have been linked to hematopoietic activity (Amemiya et al 2007). In the adult lamprey, Piavis and Hiatt (1971) confirmed that the fatty tissue rod embedded in the fibro cartilaginous sheath dorsal to the nerve cord is the principal hematopoietic organ. Scientists found that the SB is relative to the hematopoietic organ and comprises immune tissues in the lamprey because numerous immune molecules were identified in the SB of adult lamprey (Amemiya et al 2007)
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