Abstract
Delayed hypersensitivity to phytohemagglutinin and the splenomegaly assay, which is a graft-versus-host response, are accepted indicators of cell-mediated immunity in the chicken. These responses were assessed in chicks that had received either chronic (300 ppm Hg in the drinking water) or acute (five injections of 3 or 12 mg Hg/kg body weight) Hg treatments. Neither of the cell-mediated responses was affected significantly (≤.05) by the Hg treatments. This contrasts with previous work in our laboratory, which showed that chronic but not acute Hg treatments suppressed humoral immune responses. Cell-mediated immune responses in the chicken are apparently not as susceptible to the toxic effects of Hg as are humoral immune responses.
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