Abstract
Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post‐transcriptional and post‐translational regulators to determine the proteome. Furthermore, the post‐transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. WIREs RNA 2017, 8:e1419. doi: 10.1002/wrna.1419For further resources related to this article, please visit the WIREs website.
Highlights
Lymphocytes are the cells responsible for adaptive immunity in vertebrates
V(D)J recombination is a process of somatic gene rearrangement unique to lymphocytes where variable (V), diversity (D), and joining (J) gene segments, encoding the complementarity determining regions of the antigen receptors, are recombined by the activity of the recombination activating genes (RAG) to form different coding sequences resulting in a large number of receptor specificities
These experiments performed on mitogen activated mature B cells demonstrated ZFP36L1 bound to AU-rich element (ARE) in the 30UTRs of a group of mRNAs encoding proteins involved in the G1-S transition.[18]
Summary
Lymphocytes are the cells responsible for adaptive immunity in vertebrates. B cells are the subset of lymphocytes uniquely producing antibodies (secreted immunoglobulins) and recognize antigens through their B cell receptors (BCRs, transmembrane immunoglobulins). Lymphocytes must adapt to a number of distinct niches as they migrate within the bone marrow, blood, spleen, lymph nodes, and other tissues in a developmental stage appropriate manner To mediate these processes, developing lymphocytes are known to respond to environmental and developmental cues through signal transduction pathways activated by cytokine/chemokine, adhesion receptors and the antigen receptor or its precursor (the pre-BCR or the preTCR). These regulate gene expression through the expression and activation of developmental stagespecific transcription factors.[1] it is becoming increasingly apparent that the gene regulatory.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
