Abstract
Cell suspensions from the spleens of normal mice were separated by differential attachment to glass beads and plastic surfaces. Individual populations or combinations of populations were cultured in the presence of foreign erythrocytes and the number of hemolytic plaque-forming cells were measured at day 4. Marked cooperative effects were demonstrated in the size of the response when nonattached cells were cultured with small numbers of attached cells. It was shown that precursor cells were present predominantly in the nonattached cell population, and the development of a population of antibody-forming cells by day 4 was increased in the presence of attached cells. Similar cooperative effects were demonstrated when attached cells were prepared from cells obtained from the peritoneal cavity. Such cells were inhibitory at higher concentrations.
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