Abstract
The field of cellular behaviour and the biomimetic modifications on inorganic materials destined for biomedical applications shows a remarkable increase in scientific studies and, therefore, this is reflected in the investment priorities and the fundamental effort of the global research community in this area. The essential purpose of this study is to assessment the cellular behaviour of a novel TiHfNb alloy with biomimetic modification. For the mimic surface, the samples were initially bioactive with oxygen plasma or with piranha, then the following samples were biofunctionalized with APTES + maleimide and finally different surface peptide sequences were immobilized (RGD, FHRRIKA, PHSRN or 50/50 mixtures of RGD / FHRRIKA or RGD / PHSRN). To evaluate the biomimetic modification, adhesion and cell proliferation studies were carried out. Different techniques for chemical characterization were used, including: X-ray photoelectron spectroscopy (XPS), contact angle (CA), immunofluorescence, scanning electron microscope (SEM) and lactate dehydrogenase (LDH). With respect to the different peptide sequences used, the results indicated that the samples with RGD and the mixture exhibited more extended cells on the surface.
Highlights
There is an increase in the number of implants required by the population worldwide
The field of cellular behaviour and the biomimetic modifications on inorganic materials destined for biomedical applications shows a remarkable increase in scientific studies and, this is reflected in the investment priorities and the fundamental effort of the global research community in this area
Activation Process: The results indicated that Ti have a roughness 26.3 nm an TiOP 22.9nm; the samples can be considered smooth or minimally rough
Summary
There is an increase in the number of implants required by the population worldwide. Patients who need these implants desire to maintain the same level of activity and quality of life. The implants have been manufactured with different materials, such as metals and their alloys, polymers, ceramics and composite materials. A biomaterial design as an implant must provide mechanical stability, and durable bonding with the surrounding bone in a process called osseointegration. The biomaterial should avoid adverse tissue reactions and minimize the absence of infection. The most common biomaterials are metals based on Ti, Co and steel, because they have excellent mechanical properties. The polymers are the second group, the last group is composed of ceramic materials and less frequent compounds [1,2]
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