Abstract
Background and Objective:The intercourse between Esophageal squamous cell carcinoma etc. (ESC) and Celiac disease (CD) is still a complicated subject. The purpose of this research was to define the relationship between CD and ESC, and the factors associated with CD in patients with ESC.Methods:This research was conducted by Van University Medical Center in Turkey from 2012 to 2016.CD was identified by analyzing duodenal biopsy materials from 63 ESC patients via histopathologic examinations. Serum samples from the patients were also serologically tested to identify CD. A control group was selected from among subjects who underwent gastroduodenoscopy due to dyspepsia. Distinctions between case characteristics were evaluated with chi-square tests and t-tests for categorical and continuous factors, respectively.Results:Of the 63 study cases, 6 (9.5%) were both histological and serological positive for CD. Of the 290 control group, 8 (2.8%) had histopathological CD and tested positive for celiac antibodies. The patients with ESC had a significantly higher prevalence of CD compared to the dyspeptic patients (p<0.001). In addition, the mean creatinine levels of ESC patients with histopathological-proven CD were higher than those without CD (p=0.026). Furthermore, ESC patients who tested positive for tTg IgA had significantly higher levels of glucose and AST than those who were negative for tTg IgA (p=0.032) and (p=0.008), respectively.Conclusion:The present study demonstrated a statistically significant positive correlation between ESC and CD. Most remarkably, higher creatinine, glucose, and AST levels may predict CD in patients with ESC. These evidences may lead novel approaches for preventing ESC in patients with CD.
Highlights
Celiac disease (CD) is a small intestinal malabsorption syndrome caused by Correspondences: April 23, 2020 April 5, 2021 April 29, 2021 hypersensitivity to gluten in subjects who carry the HLA haplotypes HLA-DQ2 and HLA-DQ8. immune-mediated reactions result in a chronic inflammatory event in the small intestine and couse of a wide spectrum of symptoms and findings, containing diarrhea, growth failure, weightloss, anemia, arthralgia, osteopenia, and increased liver enzymes, so called transaminitis.[1]The diffusiveness of CD in the inhabitants has been calculated roughly 1% worldwide
Celiac disease (CD) is a small intestinal malabsorption syndrome caused by Correspondences: Omer Bilgehan Poyrazoglu, MD Assistant Professor of General Surgery, Nigde University Medical School, Omer Halisdemir State Hospital, Department of General Surgery, Nigde, Turkey
Pak J Med Sci September - October 2021 Vol 37 No 5 www.pjms.org.pk 1445 frequent than reported in subjects living in rural areas of the Near East.[4]. It is well-known that there is an imminent relationship between CD and enteropathy-associated T-cell lymphoma (EATL), as well as between CD and small intestinal adenocarcinoma.[5]
Summary
Celiac disease (CD) is a small intestinal malabsorption syndrome caused by Correspondences: April 23, 2020 April 5, 2021 April 29, 2021 hypersensitivity to gluten in subjects who carry the HLA haplotypes HLA-DQ2 and HLA-DQ8. immune-mediated reactions result in a chronic inflammatory event in the small intestine and couse of a wide spectrum of symptoms and findings, containing diarrhea, growth failure, weightloss, anemia, arthralgia, osteopenia, and increased liver enzymes, so called transaminitis.[1]The diffusiveness of CD in the inhabitants has been calculated roughly 1% worldwide. Are generally determined by the proximal parts of the esophagus They appear to affect older persons more, generally presenting with dysphagia, and weight loss.[6] Globally, esophageal cancer is numbered fifth in mortality rate among all malignancies, and squamous cell carcinoma stays the most common type. The “esophageal cancer zone” originates in the Far East and extends from central Asia to the Near East, with the inclusion of northern eastern Turkey, Iran, China,.[7] CD is associated with various other intestinal malignancies, including intestinal T-cell lymphoma and small bowel adenocarcinoma. ESC patients who tested positive for tTg IgA had significantly higher levels of glucose and AST than those who were negative for tTg IgA (p = 0.032) and (p = 0.008), respectively. Higher creatinine, glucose, and AST levels may predict CD in patients with ESC. These evidences may lead novel approaches for preventing ESC in patients with CD
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