Abstract
Introduction: Injection of a sublethal dose of the T cell mitogenic plant lectin concanavalin A (ConA) induces acute immune-mediated liver injury. Hallmarks of liver injury are increased plasma transaminase activities and the release of pro-inflammatory cytokines. CEACAM1 is a cellular adhesion molecule that is expressed on epithelia, endothelia, and leukocytes. Originally, CEACAM1 has been identified as an intercellular homophilic adhesion molecule on hepatocytes. The CEACAM1 isoform with a long cytoplasmic domain contains an immune receptor tyrosine-based inhibition motif (ITIM) that is pivotal in for its negative regulation of leukocyte activation.
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