Abstract
We report here CdS quantum-dots (QDs)-decorated V2O5 nanosheets as high-performance and chemically etchable photoelectric active materials for constructing a photoelectrochemical (PEC) immunoassay platform. CdS QDs-decorated V2O5 nanosheets as new photoelectric materials can show superior photocurrent to V2O5 nanosheets and CdS QDs under visible-light irradiation because of the promoted photogenerated electron-hole separation and the increased visible-light absorption. V2O5 nanosheets can be etched by ascorbic acid (AA) because of the reduction of V2O5 to V4+, and the photocurrent of CdS/V2O5-nanocomposite-modified indium tin oxide electrode decreases significantly after being etched by AA. Inspired by this phenomenon, a PEC immunoassay platform is constructed for carcinoembryonic antigen (CEA) detection by using CdS/V2O5 nanocomposite as the photoelectric material and AA-encapsulated liposome immunonanocapsules as labels. The linear detection range for detecting CEA is from 0.5 pg mL-1 to 1 ng mL-1, with a limit of detection of 0.1 pg mL-1. The proposed method also shows good selectivity, excellent reproducibility, and satisfactory recovery in detection of CEA in human serum samples. We believe that this work will lay the foundation for the future development of V2O5-based materials for PEC analysis, and also provide a reasonable design and implementation for the development of PEC immunoassay.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
