Abstract
CD8+ T Cell Control of HIV—A Known Unknown
Highlights
The former US Secretary of Defense, Donald Rumsfeld, once famously divided our areas of understanding into three categories: ‘‘known knowns ... things we know we know’’, ‘‘known unknowns ... [things we] know we ... do not know’’, and ‘‘unknown unknowns—the ones we don’t know we don’t know’’ [1]
Klatt et al and Wong et al used an approach of depleting CD8+ T cells during simian immunodeficiency virus (SIV) infection of macaques to study the mechanisms of CD8+ T cell control of virus
The groups found no difference in the decay rate of virus in CD8-depleted compared to control animals. This indicates that CD8+ T cells had no significant impact on the death rate of infected cells, suggesting that a high death rate is an intrinsic property of infected cells
Summary
The former US Secretary of Defense, Donald Rumsfeld, once famously divided our areas of understanding into three categories: ‘‘known knowns ... things we know we know’’, ‘‘known unknowns ... [things we] know we ... do not know’’, and ‘‘unknown unknowns—the ones we don’t know we don’t know’’ [1]. Klatt et al and Wong et al used an approach of depleting CD8+ T cells during simian immunodeficiency virus (SIV) infection of macaques to study the mechanisms of CD8+ T cell control of virus. Combining CD8 depletion and ART treatment allowed the two groups to study the death rate of SIV-infected cells in the presence and absence of CD8+ T cells.
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