Abstract
Abstract T cells primed in female SJL mice secrete cytokines associated with a Th1 phenotype. By contrast, T cells primed in age-matched males secrete cytokines associated with a Th2 phenotype. Gender-dependent differential activation of Th2 versus Th1 T cells correlates with increased CD4+CD25+ T regulatory cells (Treg) in males compared to females. Treg from males and females exhibit equivalent in vitro T cell suppression. However, T cells primed in males depleted of CD4+CD25+ T cells preferentially secrete IFN-g and decreased IL-4 and IL-10 compared to CD4+CD25+ T cells sufficient males suggesting that Treg influence subsequent antigen specific cytokine secretion. Treg from males exhibited increased CTLA-4 and CD62L expression and preferentially secrete IL-10. These data suggest that the increased frequency of IL-10 secreting Treg in male SJL may contribute to resistance to autoimmune disease by favoring development of Th2 immune response.
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