Abstract
Meeting abstracts The E3 ubiquitin ligase cbl-b has been identified as an important gatekeeper limiting T cell activation and more recently also NK cell activation. Hence, cbl-b deficient NK cells displayed stronger anti-tumor responses and this has been linked to a key role of cbl-b for modulation
Highlights
The E3 ubiquitin ligase cbl-b has been identified as an important gatekeeper limiting T cell activation and more recently NK cell activation
Cbl-b silenced NK cells reacted stronger to tumor cell contact and this response was synergistically enhanced by cytokine stimulation with IL-2 and IL-12
Stimulation of cbl-b silenced NK cells with cytokines in the absence of tumor cells, either with IL-2 and IL-12 or IL-2 alone led to enhanced activation of NK cells, resulting in increased secretion of effector cytokines like IFN-g and TNF-a and upregulation of the activation marker CD69
Summary
The E3 ubiquitin ligase cbl-b has been identified as an important gatekeeper limiting T cell activation and more recently NK cell activation. Cbl-b silenced human NK cells respond stronger to cytokine stimulation Cbl-b deficient NK cells displayed stronger anti-tumor responses and this has been linked to a key role of cbl-b for modulation of TAMreceptors.
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