Abstract
Understanding and controlling the interaction of cavitation bubbles and nearby material is becoming essential optimization of various processes. We examined the interaction of a single bubble with a membrane with different fluids on each side of it. Significant differences in bubble behavior depending on the fluid properties were observed, while the influence of membrane properties was less pronounced. The study has important implications, such as optimization of sonoporation (targeted drug delivery) where the mechanism, by which the permeability of the membrane is increased, is still not well understood. These results show that the focus of the optimization process should, in the first place, lie on the properties of liquids, rather than the mechanical properties of the membrane itself.
Highlights
Understanding and controlling the interaction of cavitation bubbles and nearby material is becoming essential optimization of various processes
The experiments were performed on a larger scale, with simpler materials, but effort was put into preparation and execution of experiments so that we can, at least partially, apply conclusions to, for example, sonoporation processes
The closer the densities of neighboring fluids lie, the larger is ratio of the energy which is transferred to the shock wave and the smaller is the bubble rebound. Another effect could lie in the difference in the fluids viscosity, in our preliminary study 24 on bubble dynamics near a water–oil interface we found that the differences in the behaviours of the bubble dynamics is insignificant, when oils with similar density and different viscosity are used
Summary
Understanding and controlling the interaction of cavitation bubbles and nearby material is becoming essential optimization of various processes. The study has important implications, such as optimization of sonoporation (targeted drug delivery) where the mechanism, by which the permeability of the membrane is increased, is still not well understood. These results show that the focus of the optimization process should, in the first place, lie on the properties of liquids, rather than the mechanical properties of the membrane itself. Studies of bubble interaction with thin membranes, which for example aim to investigate the mechanisms of sonoporation process[20,21], primarily focus either on the properties of the membrane (trying to make it mimic a biological structure) or the properties of the liquid. The observations are opening a new chapter in the understanding of bubble membrane interaction, which, in the past, based solely on the properties of the membrane, and not on the fluids
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