Abstract
Caveolae are membrane microdomains which play a role in vascular function. Cavin‐1/PTRF is a newly discovered protein which, in concert with the caveolins, is involved in caveola biogenesis. Our aim was to examine vascular function in mice lacking cavin‐1. We used pressure myography to examine myogenic tone and charbachol‐induced dilation in the presence and absence of L‐NAME. Blood pressure was measured in the carotid artery of anaesthetized mice. Cavin‐1‐deficient mice had significantly lower myogenic tone compared to WT (5±3% vs. 22±6% P<0.01). In the presence of L‐NAME, myogenic tone was restored towards control levels. Vessel diameter at 45mmHg was significantly larger in the cavin‐1 KO mouse compared to control (329±7 vs. 259±9 μm, P<0.05). Blood pressure was slightly lower in cavin‐1‐deficient mice (87± 7 vs. 114±9 mmHg, P<0.05). We show for the first time that cavin‐1 deficient mice exhibit abnormal vascular function, due in part to excessive NO production, and with direct consequences for the systemic blood pressure level. This work was supported by the Swedish Research Council and the Crafoord Foundation.
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