Abstract
Cavernosolide (3a), a new sesterterpene, has been isolated from the Tyrrhenian sponge Fasciospongia cavernosa. The structure was proposed on the basis of spectroscopic data and by chemical transformations. Cavernosolide showed potent activity (LC50 = 0.37 μg/mL) in the Artemia salina bioassay and a moderate toxicity (LC50 = 0.75 μg/mL) in a fish (Gambusia affinis) lethality assay.
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