Catalyzing Change: Entrepreneurs from the Global South Leading the Fight against Antimicrobial Resistance.

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Antimicrobial resistance (AMR) is rapidly emerging as one of the greatest threats to global health, with projections estimating 10 million deaths annually by 2050. The departure of major pharmaceutical companies from antibiotic research─driven by a combination of scientific complexity, low profitability, and complex regulatory hurdles─has left a serious innovation gap in the development of new antibiotics. This gap is being filled by entrepreneurial ventures in the Global South, particularly in India, South Africa, Brazil, and China, where small and medium enterprises (SMEs) now drive 80% of late-stage antibiotic development. The convergence of abundant scientific talent, cost-effective research capabilities, access to seed funding, and real-world experience with high-burden pathogens is fueling the discovery of innovative solutions to address multidrug-resistant infections. This perspective examines how these vibrant ecosystems are overcoming traditional barriers to innovation by leveraging scientific advancements, tapping into local talent, forming strategic partnerships, and developing novel business models to enable equitable access, thereby realigning public health obligations with commercial viability. This entrepreneurial endeavor in the Global South not only provides sustainable solutions to local health challenges but also contributes to the creation of a resilient global antibiotic ecosystem.

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  • 10.34172/ijhpm.2024.8471
Profits First, Health Second: The Pharmaceutical Industry and the Global South
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  • International Journal of Health Policy and Management
  • Joel Lexchin

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Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
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Assessing the impact of antimicrobial resistance policies on antibiotic use and antimicrobial resistance-associated mortality in children and adults in low and middle-income countries: a global analysis
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Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?
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Start-ups are entrepreneurial ventures, having a high risk of failure (Bortolini et al., 2018; Spender et al., 2017). The risk of failures of Start-ups can be minimized if they are characterized well, and the appropriate macro- and micro-level policy interventions can be introduced. Our literature review (LR) on Start-ups reveals that they are addressed by different names, namely, Hi-Tech firms, University spin-offs, Innovative Start-ups (ISs), Lean Start-ups, Silicon Valley Start-ups and New Technology-Based Firms (NTBF). (Tripathi, Seppanen et al., 2018; Silva et al., 2020; Wiesenberg et al., 2020). It is also observed that Start-ups are referred to as small business and Micro, Small and Medium Enterprises (MSMEs). A systematic literature review (SLR) of Start-ups is presented here and used as the basis for characterizing them. We propose (proposition-1) that these Start-up firms, addressed by different names, as referred above, can be grouped, characterized and identified as ISs. Based on a robust characterization of ISs, this article proposes that ISs are a subset of MSMEs. From a comparative study of ISs and MSME, we propose (proposition-2) a framework that shows MSMEs can be conceptually split into ISs and Conventional MSMEs (C-MSMEs), with an intersection between ISs and C-MSME. This study has also identified four new research areas related to Start-ups and MSMEs. The above characterization and differentiation of ISs from other entrepreneurial ventures will help policymakers, entrepreneurs, and investors to understand ISs and C-MSMEs better and develop suitable policy interventions and risk mitigation strategies.

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Research aims: The purpose of this study was to determine the credit distribution level used as working capital assistance for Micro, Small, and Medium Enterprises (MSMEs) during the COVID-19 pandemic.Design/Methodology/Approach: This study used a sample of 8 cities/regencies in East Java. Meanwhile, the Micro, Small, and Medium Enterprises (MSMEs) credit recipients were the population of the sample areas. This research's analysis model was panel data regression (generalized least square) by considering the emergence of heteroscedasticity in cross-section data between regional objects. The control variables outside the COVID-19 were the BI rate, third-party funds (TPF), and inflation.Research findings: This study’s results showed that the COVID-19 pandemic had a significant negative impact only on medium-sized business loans, while micro and small business loans are more resilient. Besides, Micro, Small, and Medium Enterprises (MSMEs) credit was significantly positively influenced by TPF; inflation did not affect credit; the BI rate only negatively affected medium-sized business credit.Theoretical contribution/Originality: Studies on Micro, Small, and Medium Enterprises (MSMEs) credit-related to economic phenomena and monetary policy have been widely carried out. However, the catastrophic virus that causes long-term economic uncertainty and impacts banks and Micro, Small, and Medium Enterprises (MSMEs) still requires in-depth study. Also, this study employed the GLS model that considers heteroscedasticity, which is still rarely used in previous studies.Practitioner/Policy implication: This research can be essential information for the Indonesian Financial Services Authority (Otoritas Jasa Keuangan or OJK) and Bank Indonesia (BI) in policymaking, both regulatory aspects and bank liquidity provision, in stimulating Micro, Small, and Medium Enterprises (MSMEs) credit, especially in the COVID-19 pandemic era.Research limitation/implication: The impact of COVID-19 on Micro, Small, and Medium Enterprises (MSMEs) loans is still classified based on micro, small and medium. It is still not grouped based on the Micro, Small, and Medium Enterprises (MSMEs) business sector in various cities and regencies in East Java. The analysis has not been clustered based on the spatial concentration of the Micro, Small, and Medium Enterprises (MSMEs) recipient areas.

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An investigation into the impact of the usage of debt on the profitability of small and medium enterprises in the Buffalo city municipality, South Africa
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This study investigated the impact of the usage of debt on the profitability of small and medium enterprises (SMEs) in the manufacturing sector in the Buffalo City Municipality of the Eastern Cape Province of South Africa. To achieve this objective, the research hypothesized that the usage of debt has a negative impact on the profitability of SMEs. The research further hypothesized that SMEs have a difficulty in accessing debt finance from commercial banks. The study is important because SMEs, despite their contributions to the South African economy, have not been given due attention as research on corporate finance has been biased towards large firms. The results indicated that the usage of debt has a significantly negative impact on the profitability of SMEs. The results also indicated that SMEs have difficulties accessing debt from commercial banks. Lastly, the study recommended some measures that are expected to improve the accessibility to debt and reduce the cost of debt to SMEs. These measures among others include reduction in interest rates, awareness programmes by the banks, more bank competition (specifically commercial banks that are focused on lending to SMEs) and training of the owners of SMEs in the areas of writing business plans. Key words: SMEs, debt, profitability, accessibility.

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A comparative literature review survey of employee HIV and AIDS-related corporate social responsibility (CSR) practices in small, micro and medium enterprises (SMMEs) in Zimbabwe and South Africa
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  • Tendai Makwara + 2 more

This article reviews employee HIV and AIDS-related corporate social responsibility (CSR) practices by small business in Zimbabwe and South Africa. The article aims to present a comparative snapshot of how SMMEs are responding to the epidemic as a basis for developing a CSR framework that could be implemented by SMMEs in both countries. The article applies an exploratory literature review methodology to extract data from secondary sources. Research findings show that HIV and AIDS-related CSR in Zimbabwe appear disengaged from the direct influence of corporate business, the opposite of what South African SMMEs experience. In South Africa, SMME CSR practices experience pressure from large firms. However, differences in economic status between the two countries show no effect on the CSR behaviors of SMMEs in both countries when compared with each other. In both countries, findings reveal that SMMEs hardly establish HIV and AIDS policies and therefore rely on informal CSR practices to assist employees to deal with the pandemic in the workplace. Thus, the article submits that while HIV and AIDS practices are not formalized in both countries, SMMEs fulfil their epidemic-related CSR obligations towards employees’ corresponding with their smallness. In conclusion, the study recommends an empirical examination of the research question to establish a grounded recommendation for the development of a SMMEs CSR framework that could be implemented by SMMEs in both countries.

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  • Research Article
  • Cite Count Icon 4
  • 10.4102/sajesbm.v10i1.177
Effects of knowledge management on innovation capabilities amongst small and medium enterprises in South Africa: The case of Buffalo City Metropolitan Municipality
  • Nov 28, 2018
  • The Southern African Journal of Entrepreneurship and Small Business Management
  • Courage Gwena + 1 more

Background: South Africa is witnessing a growth in small and medium enterprises (SMEs). Given this rise in SMEs, there is a need to pay attention to those factors that influence how these enterprises perform. Aim: The purpose of the study was to investigate the effects of knowledge management (KM) on innovation capabilities (IC) in SMEs with a special focus on Buffalo City Metropolitan Municipality. Setting: This study is the first to investigate the effects of KM on IC in SMEs operating in South Africa. Given the scarcity of studies on KM in SMEs in the sub-Saharan region, this study contributes to the literature on the effects of KM on IC. Method: A quantitative research approach was followed in carrying out this study. Descriptive and inferential statistics were performed to answer the research questions and test the hypotheses of the study. The respondents ( n = 280) were SME representatives operating in the Buffalo City Metropolitan Municipality. Results: Knowledge management is found to exert a positive effect on SMEs’ IC. Conclusion: Findings from the study can assist various practitioners, directly or indirectly involved with development of business, to develop strategies that improve SMEs’ growth and sustainability. These practitioners include strategic management researchers, policymakers, SME owners and managers and lecturers.

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