Abstract
AbstractSynthesis of functionalized spiro[acenaphthylene‐1,3′‐pyrrolizin]‐2‐ones and spiroindeno[1,2‐b]quinoxaline‐11,3′‐pyrrolizines has been reported by one‐pot condensation of active carbonyl compounds, L‐proline/L‐thioproline and 3‐methyl‐4‐nitro‐5‐styrylisoxazoles in MeOH under reflux. This multicomponent strategy afforded corresponding spiro products in 94–98% yield with high diastereo‐ and regioselectivity. The structure has been further confirmed by X‐ray analysis of single crystal of one of the compounds. The striking feature of this work is avoidance of usage of toxic catalysts for this one‐pot synthesis.
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