Abstract
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder of the skin, which is associated with various underlying benign or malignant neoplasms. We report a case of a 34-year-old man with rapidly progressed and extensive skin lesions, and significant weight loss. He was diagnosed as pemphigus Vulgaris with a skin biopsy firstly, then the PET/CT scan showed a retroperitoneal mass. Pathological examination of the retroperitoneal mass confirmed the diagnosis of Castleman disease with paraneoplastic pemphigus. By reporting this case, we aimed to improve the clinical alertness and awareness of Castleman disease in patients characterized by paraneoplastic pemphigus. Keywords: Paraneoplastic pemphigus, Castleman disease, paraneoplastic syndrome, hematologic malignancies
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