Abstract
The Platelia Aspergillus antigen enzyme-linked immunosorbent assay (ELISA) (Bio-Rad, Marnes-la-Coquette, France) has become an important tool for the early detection of invasive aspergillosis in immunocompromised patients (4). This ELISA uses a rat monoclonal antibody (EB-A2) which reacts with β-(1,5)-galactofuranose, a side chain of galactomannan (GM). Cross-reactivity of the Platelia ELISA with fungi other than Aspergillus was reported previously (2). Over 10 years ago, we discovered cross-reactivity of GM in antibiotics of fungal origin, such as ampicillin-sulbactam and piperacillin, by the Pastorex Aspergillus latex agglutination test, which used the same antibody (1). Industrially produced β-lactam antibiotics derived from Penicillium species also showed positive GM values in vivo (5).
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