Abstract
There are six subtypes of primary aldosteronism (PA). The most common subtype of PA is bilateral idiopathic adrenal hyperplasia (IHA) (≈60% of patients) (see Case 8). The second most common subtype of PA, in approximately 30% of patients, is caused by a unilateral aldosterone-producing adenoma (APA) (see Cases 7, 9, 12, 13, 14, and 15). The third most common subtype of PA is unilateral or primary adrenal hyperplasia (referred to as UAH or PAH). The diagnosis of UAH is based on (1) unilateral adrenal localization with adrenal venous sampling (AVS), (2) lack of an adrenal adenoma and the presence of zona glomerulosa hyperplasia on pathology, and (3) long-term cure of PA with unilateral adrenalectomy.
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