Abstract
Purpose: SIRT6 is a nuclear localized, NAD+ dependent histone deacetylase that regulates many age-associated processes, including longevity. Our recently published data indicates that active SIRT6 is a critical regulator of cartilage redox balance by increasing antioxidant levels (Prx1, Srx, Nrf2) and decreasing the levels of the pro-oxidant, TXNIP. Importantly, our data also demonstrates that SIRT6 activity declines with age. To build on these findings in vivo, this study aimed to define the effect of Sirt6 loss on the development of DMM-induced OA in mice.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
