Abstract
The effects of cocaine-and amphetamine-regulated transcript (CART) peptide on extracellular concentrations of dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the shell region of the nucleus accumbens (AcbSh) were determined by microdialysis in conscious rats. Intracerebroventricular injections of various doses (0.1–5 μg/5 μl/rat) of CART 55–102 elicited dose-dependent increases of extracellular DOPAC and HVA concentration in the AcbSh, suggesting that CART 55–102 peptide has a psychostimulant-like effect via activation of the mesolimbic dopaminergic system.
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