Carotid Intima-media Thickness is a Sequel of Elevated FGF-23 Levels in CKD!

Abstract

International Journal of Medicine and Public Health,2022,12,4,165-168.DOI:10.5530/ijmedph.2022.4.30Published:January 2023Type:Original ArticleCarotid Intima-media Thickness is a Sequel of Elevated FGF-23 Levels in CKD!Upma Narain, Arvind Gupta, and Seema Pandey Upma Narain1,*, Arvind Gupta2, Seema Pandey3 1Microbiologist and Immunologist, Tejas Microdiagnostics, Prayagraj, Uttar Pradesh, INDIA. 2Department of Nephrology, MLN Medical College, Prayagraj, Uttar Pradesh, INDIA. 3Department of Radio Diagnosis, MLN Medical College, Prayagraj, Uttar Pradesh, INDIA. Abstract:Background: FGF-23 regulates phosphate homeostasis and has a correlation with morbidity and mortality due to cardiovascular episodes and chronic renal conditions. The risk of subclinical atherosclerosis can be predicted by measurements of the intima-media thickness of the carotid artery. The objective of this studyisto study therelation between serum FGF-23 levels and Carotid intima-media thickness in the early stages of CKD. Materials and Methods: This study was conducted at MLN Medical College, SRN Hospital, Prayagraj and Tejas Microdiagnostics. The study design adopted was prospective and observational. A total of 270 newly diagnosed CKD patients were enrolled as cases while 90 patients without CKD were taken as control. Highresolution ultrasonography was utilised to measure Carotid artery intima-media thickening. Serum FGF-23 levels were performed at the beginning of study, along with other baseline investigations and were repeated on 6th and 9th months respectively. Results: Among the case group of CKD, the mean age was 54.8+2.1 years with male to female proportions representing 62% and 38%, respectively of the control group consisted mean age distribution of 51.0 + 2.1 years a and male-female proportion of 58% and 42%, respectively. It was observed that FGF-23 levels and Carotid intima-media thickness measurements were high in patients than in controls. A statistically significant correlation at 0.01 levels was observed between FGF-23 and the Carotid intima-media thickness. Conclusion: Our study clearly establishes a strong correlation between FGF-23 and CIMT indicating that FGF-23 plays an important role in the development of vascular calcifications in early stages of CKD. Subclinical atherosclerosis in CKD patients can be predicted by monitoring of their FGF-23 and CIMT level. Keywords:Association, Carotid intima-media thickness, CKD, FGF-23View:PDF (347.97 KB)