Abstract
Several antioxidant nutrients have been described to inversely correlate with asthma. In order to quantify the intake of these substances, it is possible to measure skin levels by Raman spectroscopy, a novel non-invasive technique that can also be used in children. This cross-sectional school-based study involved 423 children from a rural area of Thailand. Asthmatic children were diagnosed according to a Health Interview for Asthma Control questionnaire. Skin carotenoid levels were measured with Raman spectroscopy. Demographic data were obtained by directly interviewing children and their parents, whereas anthropometric parameters were measured by trained staff. Intake of carotenoids, vitamin A and C were evaluated by a food frequency questionnaire. Overall incidence of asthma in Thai schoolchildren (aged 3.5–17.8 years) was 17.3%. There was no significant difference in dietary intake of carotenoids and vitamin A and C, and skin carotenoid level between asthmatic and non-asthmatic children. Skin carotenoid level significantly correlated with all carotenoids and vitamin A intake (P<0.05). Carotenoids and vitamin A and C intakes, and skin carotenoid levels were not associated with the risk of asthma in Thai children. Skin carotenoids correlated with all carotenoids and vitamin A intake in mild to moderate degrees. Raman spectroscopy was confirmed to be a useful tool to determine antioxidant skin levels.
Highlights
There was no significant difference in dietary intake of m carotenoids and vitamin A and C, and skin m carotenoid level between asthmatic and nonasthmatic children
Systehad smokers in the family were dis- the parents.[20] matic review of worldwide variations of the tributed between the two groups
Raman spectroscopy directly correlates serum antioxidant levels to those of skin,[23] is less invasive than serum measurements, and easier to use in children
Summary
LR co-designed the experiment, and co-worked on associated data collection and their interpretation. Children who had skin lesions at the area of measurement of skin carotenoids were excluded. Trained staff collected demographic data by interviewing children and their parents. Interview Survey for Asthma Control (sample spectroscopy was confirmed to be a useful tool A cross-sectional school-based study was core: children)[16] to classify asthmatic children. Conducted in schoolchildren in one school of According to this, a child was considered asththe Ongkaluck district, a rural region in central matic when a doctor or other health profes-. Thailand, during November and December sional had diagnosed asthma in the previous
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