Abstract
Carnitine effects on serum and pancreas inflammatory response in diabetic rats
Highlights
Diabetes is a chronic and endocrine disorder
Our results showed that L-carnitine i.p. administration has valuable effects which attenuated pro-inflammatory cytokines levels in pancreas and serum of STZ-induced diabetic rats
We found that 300 mg/kg/day of L-carnitine is very effective compared to other doses we administrated in this study
Summary
Diabetes is a chronic and endocrine disorder. It was estimated that it affects about 438 million people by 2030worldwide [1]. FFAs are able to promote IL-1β and IL-6 secretion and long exposure of pancreatic β-cell to these inflammatory agents lead to free radical activation and β-cell apoptosis [2, 8] It seems that IL-1 is highly involved in the β-cell inflammatory process. In a case-control study, Lee and colleagues investigated L-carnitine anti-inflammatory properties of L-carnitine in CAD patients They found that L-carnitine administration (1 gr/d) reduced inflammation in patients with CAD after 12 weeks [20]. There was no study which evaluated L-carnitine effects on pro-inflammatory cytokines in diabetic models. We aimed to evaluate the effect of different doses of L-carnitine on blood glucose and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in serum and pancreas tissue of STZ-induced diabetic rats
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