Abstract

ObjectiveTo determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well-characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.MethodsData on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.ResultsPrimary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age- and sex-matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.ConclusionPrimary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age- and sex-matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.

Highlights

  • The association between cardiovascular risk and chronic multisystem inflammatory conditions has been the subject of a large body of research

  • The prevalence of hypertension, hypercholesterolemia, and hypertriglyceridemia was higher among primary s syndrome (SS) patients compared to healthy controls

  • Since age is a key determinant of blood pressure and serum lipid levels, we stratified the prevalence of hypertension, hypertriglycemia, and hypercholesterolemia according to age and demonstrated that the percentages of primary SS patients with hypertension or hypertriglyceridemia were higher than healthy controls in all age categories

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Summary

Objective

To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well-characterized primary Sjogren’s syndrome (SS) patients and to compare them to healthy controls. Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group. Primary SS patients had a higher prevalence of hypertension (28 –50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P ‫ ؍‬0.002) than age- and sex-matched healthy controls. Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than ageand sex-matched healthy controls. Hypertension is underdiagnosed and suboptimally treated in primary SS

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