Abstract
PURPOSEIn the present study, a cross‐sectional investigation of 769 Japanese men and women (18–75 years old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and beta3‐adrenergic receptor (ADRB3) Trp64Arg gene polymorphism.METHODSCommon carotid intima‐media thickness (ccIMT) was assessed as a risk of atherosclerosis. We measured peak oxygen uptake (VO2peak) during incremental cycle ergometer exercise test, and then the subjects were divided into high‐(High‐Fit) and low‐cardiorespiratory fitness (Low‐Fit) groups based on the median value of VO2peak in each sex and decade.RESULTSBody fat, triglyceride and plasma glucose levels were lower and HDL cholesterol levels and VO2peak were higher in High‐Fit subjects compared with in Low‐Fit subjects, but there were no significant effect of ADRB3 polymorphism. There was no significant effect of ADRB3 Trp64Arg polymorphism on ccIMT. In Low‐Fit subjects, ccIMT increased in ArgArg genotype individuals compared with TrpTrp and TrpArg genotype of ADRB3, however, had no effect on ADRB3 polymorphisms in High‐Fit subjects.CONCLUSIONThese results suggest that the higher cardiorespiratory fitness may attenuate a risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism.This work was supported by a Grant‐in‐Aid for Scientific Research of Japan (#20300231, #20700563).
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