Abstract
Cardiac arrhythmia is an abnormal rate and/or rhythm of a heart due to its abnormal electrical impulse origination and/or propagation. Various etiologies can cause arrhythmias. Heart failure (HF) is a clinical syndrome due to an impaired heart that can not pump sufficient blood to meet the systemic metabolic needs. The common causes of HF include myocardial infarction, hypertension, valvular heart disease, and cardiomyopathy. [1] The morbidity and mortality of HF and cardiac arrhythmia are high in the aging population aged ≥ 65 years. This geriatric population in the world is predicted to be 973 million by the year 2030. [2] In USA, elderly patients account for more than 85% of all cardiovascular disease deaths, 65% of cardiovascular disease hospitalizations, 62% of myocardial infarction hospitalizations, and 77% of HF hospitalizations. [3–5] Therefore, the Journal of Geriatric Cardiology organized this special issue, Cardiac Arrhythmia and Heart Failure: from Bench to Bedside. This issue contains several reviews and research articles contributed by a group of scientists from different institutions. These articles include the authors own and others’ research from bench at the molecular and cellular levels to bedside of the treatment and management of cardiac arrhythmia and heart failure. Mitochondria are organelles found in almost all cells in our body and generate 90% or more of the energy for cell use. [6] Aging can cause cellular and sub-cellular structural alteration and dysfunction. In early 1970s, Dr. Harman proposed the mitochondrial theory of aging. [7] As myocardium
Highlights
As myocardium heavily depends on oxidative metabolism and consumes a lot of energy, mitochondrial dysfunction can cause heart failure, or vice versa
Dr Huang and his colleagues had investigated the potential mechanisms underlying restrictive cardiomyopathy (RCM) development and progression in a transgenic RCM animal model.[9,10]. They reviewed the progress in RCM research from basic to clinical studies, especially from RCM transgenic animals.[11]
The morbidity and mortality of cardiac arrhythmia and Heart failure (HF) are much high in the geriatric population
Summary
Mitochondria are organelles found in almost all cells in our body and generate 90% or more of the energy for cell use.[6] Aging can cause cellular and sub-cellular structural alteration and dysfunction. In early 1970s, Dr Harman proposed the mitochondrial theory of aging.[7] As myocardium heavily depends on oxidative metabolism and consumes a lot of energy, mitochondrial dysfunction can cause heart failure, or vice versa.
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