Abstract
Cardiac apoptosis (CA) is involved in doxorubicin (DOX) induced cardiotoxicity. Aim of this study was to assess the influence on CA of different exposure times to the same DOX cumulative dose (20 mg/kg) in rats. DOX was administered intraperitoneally four times per week at the following doses: a) 5 mg/kg/day for 1 week; b) 2.5 mg/kg/day for 2 weeks; c) 1.25 mg/kg/day for 4 weeks. Western blot analysis of cardiac protein expression was performed 48 h after first DOX injection and at the end of treatments.
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