Abstract
BackgroudWe investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI).MethodsFifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients.ResultsThe aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus.ConclusionsThis study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI.
Highlights
Results amnestic mild cognitive impairment (aMCI) patients versus controls The demographics of the patients and the normal population are outlined in the Table 1
The results of our study showed that patients with aMCI compared to normal subjects had lower performances in both card-placing test (CPT) A and CPT B
The study suggested that multiple domain aMCI is a transitional state between single domain aMCI and Alzheimer’s disease (AD), and that the cortical thinning is evidence that the precuneus is responsible for the multiple cognitive impairments in multiple domain aMCI. Both possible explanations for our result suggest that the CPT B may reflect the functional status of the posterior cingulate gyrus, we performed further correlational analyses with Mini-Mental State Examination (MMSE) and neuropsychological tests covering each cognitive domain and metabolism on fluoro-deoxy-glucose positron emission tomography (FDG-PET) to distinguish two hypotheses
Summary
In our study, using statistical parametric mapping (SPM) analysis we aimed to investigate anatomical correlates of the CPT in fluoro-deoxy-glucose positron emission tomography (FDG-PET) studies of patients with amnestic MCI
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