Abstract
The bronchodilator effect of ipratropium bromide (IB) (Atrovent-Sch 1000), 40 μg inhaled, and metaproterenol (Met), 1.25 mg in various combinations, was compared in ten allergic asthmatic patients, aged 23 to 63 years. Six combinations were used at random in a double blind study. The following ventilatory functions—FVC, TGV, SGAW, FEV1, FEF 25-75, V⋅Emax, V⋅E50, V⋅E25, were measured at 30 min. intervals for the first two hours and at 60 minute intervals for the additional three hours. Inhalation of IB followed by Met resulted in additive bronchodilator effect that was significantly greater and longer than EB alone (p<0.05), Met alone (p<0.05), two consecutive inhalations of Met (p<0.05), or Met followed by IB (p<0.05). The bronchodilating effect of EB and Met after five hours was the same as IB after one hour.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
