Abstract
Herein, a novel, flexible and inexpensive carbon-cloth based electrochemical device (CCED) is proposed with polyimide (PI) sheet as a base substrate. CC, embedded with numerous microfibers, was used as a sensing substrate. A CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laser was employed for laser cutting three CC electrodes with desired dimensions, which were bonded on the PI sheet using a double-sided tape. Unmodified CC was used as working and counter electrodes, whereas Ag/AgCl ink modified CC was a reference electrode. For creating a hydrophobic region and insulating the electrodes, lamination process was used. Further ascorbic acid (AA) and tryptophan (Tr) were used as analytes for sensing with natural and unmodified CCED surface. The electrochemical response was analyzed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the CCED was observed to be capable of determining AA and Tr in a neutral pH (phosphate buffer solution) at 0.4 V and 0.6 V in a linear range of 30 - <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$8000 ~\mu \text{M}$ </tex-math></inline-formula> and 20 – <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$6000 ~\mu \text{M}$ </tex-math></inline-formula> , with LOD of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$21.76 ~\mu \text{M}$ </tex-math></inline-formula> , and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$11.84 ~\mu \text{M}$ </tex-math></inline-formula> respectively at (S/N=3). Additionally, it was thoroughly investigated for common interfering species including Xanthine (Xn), Hypoxanthine (Hx), Uric acid (UA), Cysteine (Cy), Glucose (G) and Folic Acid (FA). The sensing platform was successfully applied for determination of AA and Tr in human real serum sample with appreciable recoveries.
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