Abstract
Silica microspheres (SMs) feature non-toxic and high chemical stability, which have a wide range of applications in sensors, photosensitive emulsion and medicine. However, applying SMs as catalysts for synthesis of fine chemicals in organic and medical chemistry field has few been reported before. In this work, SMs were efficiently synthesized through hydrolysis and polycondensation reaction of ethyl orthosilicate (TEOS) in an alkaline system, and the surface modified SMs catalysts were successfully prepared by the impregnation method. The surface modified SMs catalyzed X − H (X = C, O, N, S) and C C bonds insertion reactions from various diazo compounds with acyclic and cyclic 1,3-dicarbonyl compounds, arylamines and thiophenols were reported, giving the corresponding products in moderate to excellent yields. The modified species played the key role in the reactions and were identified as the catalytic active species. HRTEM and XRD revealed that the modified species are highly dispersed on the modified SMs surface.
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