Carbene adduct of cyclopalladated ferrocenylimine‐assisted synthesis of aminopyridine derivatives by the amination of chloropyridines with primary and secondary amines

Abstract

An efficient, simple way to synthesize aminopyridine derivatives is presented, based on Buchwald–Hartwig aminations. Using 1 mol% N‐heterocyclic carbene adduct of cyclopalladated ferrocenylimine in the presence of 1.5 equiv. tBuOK as base in dioxane at 110°C offered moderate to excellent yields in the reaction of chloropyridines with primary and secondary amines, including sterically hindered amines and alkyl amines.