Molecular therapy oncolytics | VOL. 25
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CAR Tcell therapy and the tumor microenvironment: Current challenges and opportunities.

Publication Date Jun 16, 2022

Abstract

Chimeric antigen receptor (CAR) Tcell therapy has demonstrated remarkable outcomes in individuals with hematological malignancies, but its success has been hindered by barriers intrinsic to the tumor microenvironment (TME), particularly for solid tumors, where it has yet to make its mark. In this article, we provide an updated review and future perspectives on features of the TME that represent barriers to CART cell therapy efficacy, including competition for metabolic fuels, physical barriers to infiltration, and immunosuppressive factors. We then discuss novel and promising strategies to overcome these obstacles that are in preclinical development or under clinical investigation.

Concepts
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Chimeric Antigen Receptor Tcell Therapy
Chimeric Antigen Receptor
Tumor Microenvironment
Outcomes In Individuals
Immunosuppressive Factors
Tcell Therapy
Antigen Receptor Tcell Therapy
Hematological Malignancies
Current Challenges
Future Perspectives

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