Capturing group variability using IVA: A simulation study and graph-theoretical analysis

Abstract

When applied to functional magnetic resonance imaging (fMRI) data, independent vector analysis (IVA) provides superior performance in capturing subject variability within one group, as compared to the widely used group independent component analysis (ICA) approach. However, the effectiveness of IVA algorithms in preserving variability between different groups of subjects has not been studied yet, although it is of great interest in most fMRI studies, especially for identifying biomarkers for diagnosis of mental disorders. In this paper, we introduce a methodology that uses graph-theoretical analysis and statistical analysis for assessing the ability of IVA algorithms to capture group variability. We generate multi-subject fMRI-like datasets with increasing spatial variability for a selected component between two groups and compare a robust IVA algorithm to group ICA approach. Our experimental results show that IVA can successfully preserve group variability, indicating its potential in extracting biomarkers across groups of subjects in fMRI analysis.