Abstract
Infection of goat synovial membrane (GSM) cells by caprine arthritis-encephalitis virus (CAEV) was inhibited by incubation of cells with CAEV gp 135 envelope glycoprotein (SU) expressed by recombinant vaccinia virus. Incubation of cells with protein expressed by a control recombinant vaccinia virus without the CAEV envelope gene did not inhibit CAEV infection. Removal of recombinant SU from blocking medium by adsorption with anti-SU IgG/protein G-Sepharose complexes resulted in loss of CAEV inhibition. Results support that CAEV infection of GSM cells is mediated by a specific interaction between SU and a cell surface receptor or receptor complex.
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