Abstract
A tris(hydroxymethyl)aminomethane-acetate buffer system with methanol as solvent has been used at an apparent pH of 8.5 for the separation of six aromatic and aliphatic acids. Compared to pure aqueous buffer systems with various pH values (4.4, 5.5, 6.2 and 8.0) improved separation was obtained due to increased selectivity. This improvement is related to a specific shift in the p K a values of the solutes in the organic solvent, and is interpreted by the concept of the transfer activity coefficient and the medium effect.
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