Abstract
A large group of biologically active compounds that influence cannabinoid receptors—cannabinoids—is considered. The modern concepts of endocannabinoid neurotransmitter systems, their modulation, and biological role are described. Chemical classification of the ligands of cannabinoid receptors and the patterns of signal transduction in endocannabinoid systems are discussed. The leading role of neurochemical and neurobiological components contributing to cannabinoid dependence is substantiated. In addition, changes in endocannabinoid systems play an important role in the pathogenesis of other chemical dependences. Therefore, the modification of endocannabinoid systems with the help of various remedies is a promising trend in the prevention and treatment of both cannabinoid addiction and dependences on other psychoactive drugs.
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