Abstract
Global Health Much of what is known about the signature genetic alterations and clinical features of cancer comes from studying Caucasian patients in high-income countries. However, this does not reflect the diversity of heritage in most societies and therefore does not allow patients to be diagnosed and treated effectively. In a Perspective, Rebbeck discusses the emerging evidence that cancers in patients in sub-Saharan Africa are clinically and molecularly distinct. Understanding these differences should improve treatment of patients in sub-Saharan Africa as well as the diaspora. Assessment of the diversity of genetic alterations can also improve how cancer is diagnosed and classified in all populations. Science , this issue p. [27][1] [1]: /lookup/doi/10.1126/science.aay4743
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