Abstract
Aim : The aim of this study is to determine the effectiveness of the neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in the diagnosis of acute cholecystitis (AC). Material and method : 452 patients diagnosed with AC and 152 patients who admitted to the clinic with biliary colic and elective cholecystectomy have been included this study. Groups compared according to age, gender, white blood cell count (WBC), mean platelet volume (MPV), platelet distribution width (PDW), red blood cell distribution width (RDW), NLR and PLR. Results : There was no significant difference in age between the two groups (p=0.52). Female patients were significantly higher in both control and AC groups (p=0.006). WBC, CRP, NLR, PLR values of the patients in the study group have been observed significantly higher than the control group (p<0.001). The parameter with the highest sensitivity and specificity was found as NLR. Conclusions: NLR and PLR can be considered as a potential inflammatory biomarker for AC, due it being inexpensive and easy calculated.
Highlights
Acute cholecystitis (AC) is one of the most common causes of patients presenting with abdominal pain to the emergency department (ED) [1]
white blood cell count (WBC) and C-reactive protein (CRP) levels were significantly higher in AC group (p
This study investigated the effectiveness of WBC, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and CRP in prediction of AC using Receiver Operating Characteristic (ROC) analysis
Summary
Acute cholecystitis (AC) is one of the most common causes of patients presenting with abdominal pain to the emergency department (ED) [1]. About 90% of patients, inflammation of the biliary system occurs due to obstruction of the bile duct by gallstones [2]. Delayed management may lead the aggravation to severe cholecystitis situations that increases morbidity such as gangrenous changes, perforation, etc. The Tokyo Guidelines (TG 18), which include criteria that are classified as clinical markers and ultrasonography (USG) findings of inflammation, are often used for diagnosis [4]. The gold standard diagnostic method for AC is USG. USG may not always be available, useful bedside tests are required [5,6]
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