Abstract
ABSTRACTPurpose To evaluate the usefulness of natural killer cell activity (NKA) in diagnosing prostate cancer (PC).Materials and Methods The medical records of patients who underwent transrectal prostate biopsy (TRBx) at Korea University Ansan Hospital between May 2017 and December 2017 were retrospectively reviewed. NKA levels were measured using NK Vue® Tubes (ATgen, Sungnam, Korea). All blood samples were obtained at 8 AM on the day of biopsy. Patients with other malignancies, chronic inflammatory conditions, high prostate-specific antigen (PSA) level (>20ng/mL), or history of taking 5-alpha-reductase inhibitor or testosterone replacement therapy were excluded.Results A total of 102 patients who underwent TRBx for PC diagnosis were enrolled. Among them, 50 were diagnosed with PC. Significant differences in age and NKA level were observed between the PC and no-PC groups. Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off of NKA level for the prediction of PC was 500pg/dL, with a sensitivity of 68.0% and a specificity of 73.1%. In addition, NKA level (0.630) had the greatest area under the ROC curve compared to those for the ratio of total PSA to free PSA (0.597) and PSA density (0.578).Conclusions The results of this pilot study revealed that low NKA and high PSA levels were likely to be associated with a positive TRBx outcome. NKA detection was easy and improved the diagnostic accuracy of PC.
Highlights
Prostate cancer (PC) is one of the most common malignancies in Korean men [1]
The prostate-specific antigen (PSA) level is widely used in the diagnosis and follow-up of PC, and the increase in the incidence of PC has been attributed to the widespread testing of PSA level in daily clinical practice [2]
Significant differences in free PSA and prostate volumes were observed according to natural killer cell activity (NKA) level
Summary
Prostate cancer (PC) is one of the most common malignancies in Korean men [1]. The prostate-specific antigen (PSA) level is widely used in the diagnosis and follow-up of PC, and the increase in the incidence of PC has been attributed to the widespread testing of PSA level in daily clinical practice [2]. Patients with PSA levels >3.5-4.0ng/mL may be recommended to undergo prostate biopsy. The American Cancer Society reported that the sensitivity of PSA for PC detection is only 21%, whereas the specificity is 91% when the normal PSA level is defined as
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International braz j urol : official journal of the Brazilian Society of Urology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
